The enactment of freezing-drying
curve
Academy of Military Medical Sciences experiment instrument plant senior engineer original factory director WangLiHua
I am engaged in developing
of the vacuum freeze dryer machine and Level
analysis congealer and other experiments for
more than 20 years. I am the two representative
directors of items which holding the post of
"95" national science and technology
departments to offend pass topic. Now I’m the
general manager of BeiJing SongYuan HuaXing
Technology Development Co. Ltd.
Here is my viewpoint about the effect of drying
curves in the process of freezing-drying, now
I provide it for you for your information:
The freezing-drying products of biological products
need to have certain physical appearance, even
color, qualified of cripple remaining water
content, good deliquescence, efficiently of
livability, longer conservancy period, therefore
not only create process and seal preservation
before the freeze-drying should be controlled.
What’s more important is to carry on the comprehensive
control of each stage’s parameter of the freeze-drying
process, then you can get a high-quality product,
drying curves is the basic basis to carry on
the control of the freeze-drying.
The drying curves is the curve relation between
the freeze box’s temperature and time, taking
temperature as vertical ordinate and time for
horizontal ordinate sit a mark, it reflects
different time flag temperature’s change situation
during the freezing and drying process.
The freezing and drying curve take the flag
temperature as basis, because the product is
controlled by the flag temperature, the flag
temperature has also controlled the product’s
temperature, the enactment of freezing and drying
curve needs to consider the factors as follows:
The species of product, different product’s
altogether melting point is different, altogether
melting point product requests the low pre-frozen
temperature, heats up when the flag temperature
corresponding is also low, must act according
to experiments discovers a product the most
superior freezing speed, by obtains the high
grade product and the short freeze-drying time.
Time dissimilarity is also request to remnants
remaining water different, keeping time dissimilarity
is also request to remnants remaining water
different, to drying time correspond also different,
how much pack quantity, the species of airtight
machine, freeze dryer machine of function's
etc. The factors are relate to a curve of establish,
customer should according to freeze dryer product
of property, according to former of freeze dryer
experience, set the drying curves, in order
to get high-quality of freeze dryer product.
The machine can be provided as customer to
establish drying curves arbitrarily according
to the effective demand.